Chemotherapy can be offered, except for the first trimester, taking into account the risk of malformations. The first line of treatment is considered to be surgery indicated in any trimester of pregnancy, with mastectomy being often used. The diagnosis of breast cancer during pregnancy or breastfeeding is a challenging situation considering the physiological changes.

The decisions regarding the most appropriate therapeutic methods should be made by a multidisciplinary team after offering counseling to the patient.

It represents a special situation which requires careful attention for the medical team in fulfilling the goals of the treatment: the cure of the disease and the well-being of the pregnancy. Pregnancy-associated breast cancer is one of the leading pregnancy-related types of cancer with an increasing incidence. Treatment should be started promptly during pregnancy. Conclusion: The poor prognosis of the pregnancy-associated breast cancer is no longer attributed to pregnancy but rather to the young age of the patients and the delay in the diagnosis of cancer. After a 5-year follow-up, two of eighteen patients died and six were lost to follow-up. On the other hand, radiotherapy, antiestrogens (Tamoxifene) and targeted therapies (Herceptin) must be postponed after delivery because of their teratogenic effects. Chemotherapy was allowed during pregnancy, and was given to 23 patients. Twenty patients underwent surgical treatment by mastectomy and breast-conserving surgery (lumpectomy) associated with axillary lymph node dissection was performed in three cases. The mean gestational age at which delivery occurred was 35.4 weeks. Pregnancy was completed in nine patients. The most common histological type was infiltrating ductal carcinoma (96% of cases). Pathohistological diagnosis was established by ultrasoundguided biopsy and surgical biopsy in fourteen and seven patients, respectively. Breast cancer was diagnosed during pregnancy in fourteen patients and after delivery in eleven patients.

Results: The mean age of the patients was 35.84 years. Methods and materials: Our study design is retrospective based on 25 cases of pregnancy-associated breast cancer, carried out at the Maternity and Neonatology Center of Tunis over a period of 10 years, between January 2001 and December 2013. Objectives: This document aims to identify the clinical, therapeutic, and prognostic features of this association and to provide the up-to-date management.

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